Shorter Injectable-containing MDR/RR-TB Regimen: Regimen and Duration

The shorter injectable-containing MDR/RR-TB Regimen consists of 4 to 6 months of intensive phase with high dose moxifloxacin, Kanamycin/Amikacin (injectable), Ethionamide, Clofazimine, Pyrazinamide, high dose isoniazid and ethambutol and a 5-month continuation phase with high dose moxifloxacin, Clofazimine, Pyrazinamide and Ethambutol. This regimen can be written in the following abbreviated form.

(4-6) Mfx^h, Km/Am, Eto, Cfz, Z, H^h, E/ (5) Mfx^h, Cfz, Z, E

Mfx^h- High dose moxifloxacin

Km/Am- Kanamycin/Amikacin

Eto- Ethionamide

Cfz-Clofazimine

Z- Pyrazinamide

H^h -High dose Isoniazid 

E- Ethambutol

Note:

• If the intensive phase is prolonged, the injectable agent (Km/Am) is only given three times a week in the extended intensive phase;
• Neither replacement of drug (except the use of Am instead of Km) nor extension of treatment duration (beyond 11 months) is permitted; and
• Pyridoxine is to be given as per weight band.

Resources

• Guidelines for Programmatic Management of drug resistant tuberculosis in India-2021

Assessments