Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen: Pre-treatment Evaluation [PTE]

There are two main evaluations that must be conducted during pre-treatment evaluation to initiate patients on a shorter oral bedaquiline-containing MDR/RR-TB regimen. These evaluations are:

Clinical Evaluation

• History and physical examination
• Height check
• Weight check
• Psychiatric evaluation, if required

Laboratory-based Evaluation

• Random Blood Sugar (RBS)​
• HIV testing following counselling
• Complete blood count (Haemoglobin (Hb), Total Leucocyte Count (TLC), Differential Leucocyte Count (DLC), platelet count)​
• Liver function tests (including serum proteins Thyroid-stimulating Hormone (TSH) levels) 
• Urine examination – routine and microscopic​ 
• Serum electrolytes (Sodium (Na), Potassium (K), Magnesium (Mg), Calcium (Ca))​ 
• Urine pregnancy test (in women of reproductive age)​ 
• Chest X-ray
• Electrocardiogram (ECG)​     

Resources​

• Guidelines for Programmatic Management of Drug-resistant Tuberculosis in India, March 2021.
• WHO Consolidated Guidelines on Tuberculosis: Module 4-Treatment: Drug-resistant TB Treatment, 2020.

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